PARANEOPLASTIC ECZEMA AS AN INITIAL MANIFESTATION OF A RENAL CELL CARCINOMA
DOI:
https://doi.org/10.12955/pmp.v2.167Keywords:
Renal cell carcinoma, Paraneoplastic syndrome, Kidney cancerAbstract
Paraneoplastic skin manifestations are well-known accompanying disorders in cases with a malignant tumor. If not treated, some may lead to serious disability. In fact, these conditions disappear after the tumor removal. Plantar hyperkeratosis as the first manifestation of clearcell renal cell carcinoma has not been reported. We present a patient with severe untreatable hyperkeratosis of the soles of the feet. The paraneoplastic etiology of the eczema was suggested, and a left kidney tumor was diagnosed and operated. Rapid improvement of the keratoderma eczema was observed within a week of the tumor removal. The patient has no local and distant metastases.
Paraneoplastic skin manifestations as initial syndromes of malignant disease can help in the early diagnosis of cancer at a stage that allows complete cure.
References
Azulay RD, Azulay DR, Abulafia LA. Sinais malignos na pele versus síndromes paraneoplásicas cutâneas: revisão. An Bras Dermatol. 2000;75:621-30.
Curth HO. Skin lesions and internal carcinoma. In: Andrade R, editor. Cancer of the Skin: Biology, Diagnosis, Management. 1976: 1308–41
Dourmishev LA, Draganov PV. Paraneoplastic dermatological manifestation of gastrointestinal malignancies. World J Gastroenterol. 2009;15:4372-9.
Gold PJ, Fefer A, Thompson JA. (1996) Paraneoplastic manifestations of renal cell carcinoma. Semin Urol Oncol. Nov;14(4):216-22. PMID: 8946620.
Has Cristina, Technau-Hafsi Kristin (2016) Palmoplantar keratodermas: clinical and genetic aspects,
Journal der Deutschen Dermatologischen Gesellschaft, https://doi.org/10.1111/ddg.12930
НLers BH, Sahn RE, Callen JP (2009) Cutaneous manifestations of internal malignancy. CA: ACancer J Clinicians 59:73-98.
Kallini JR, Sadeghani K, Khachemoune A (2017) Paraneoplastic palmoplantar keratoderma secondary to metastatic uterine adenocarcinoma. Cutis 99: E32-5
Khoschbin T, Loser C, Dippel E. (2019) Paraneoplastic skin diseases. Internist, 60, 775–782.
Miyashiro D, Sanches JA. (2016)Paraneoplastic skin disorders: A review. G. Ital. Dermatol. Venereol., 151, 55–76.
Palapattu GS, Kristo B, Rajfer J. (2002) Paraneoplastic syndromes in urologic malignancy: the many faces of renal cell carcinoma. Rev Urol.;4(4):163-170.
Pipkin CA, Lio PA. (2008) Cutaneous manifestations of internal malignancies: an overview. Dermatol Clin.;26:1–15.
Ramos-E-Silva M, Carvalho JC, Carneiro SC. (2011) Cutaneous paraneoplasia. Clin Dermatol.;29:541–7.
Silva JA, Mesquita Kde C, Igreja AC, et al. (2013) Paraneoplastic cutaneous manifestations: concepts and updates. An Bras Dermatol.;88(1):9-22. doi:10.1590/s0365-05962013000100001
Schiller S, Seebode C, Hennies HC et al. Palmoplantar keratoderma (PPK): acquired and genetic causes of a not so rare disease. J Dtsch Dermatol Ges 2014; 12(9): 781–8.
Stollmeier A, Rosario BA, Mayer BL, et al. (2016) Seborrheic Keratoses as the First Sign of Bladder Carcinoma: Case Report of Leser-Trélat Sign in a Rare Association with Urinary Tract Cancer. Case Reports in Medicine:4259190. DOI: 10.1155/2016/4259190.
Yan K, Liu C, Xu Z, Liu Z, Wang K, Jiang Y, Fan Y. (2013) Renal cell carcinoma presenting as exfoliative dermatitis (erythroderma) - a case report. Clin Nephrol.;80(1):63-6. doi: 10.5414/CN107319. PMID: 22575379.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2021 Author
This work is licensed under a Creative Commons Attribution 4.0 International License.
The author is the copyright holder. Distribution license: CC Attribution 4.0.
