• Vanya B. Georgieva Sofiamed Hospital, Sofia University St. Kliment Ohridski, Sofia
  • Tsvetelina V. Markova Sofiamed Hospital, Sofia University St. Kliment Ohridski, Sofia



Renal cell carcinoma, Paraneoplastic syndrome, Kidney cancer


Paraneoplastic skin manifestations are well-known accompanying disorders in cases with a malignant tumor. If not treated, some may lead to serious disability. In fact, these conditions disappear after the tumor removal. Plantar hyperkeratosis as the first manifestation of clearcell renal cell carcinoma has not been reported. We present a patient with severe untreatable hyperkeratosis of the soles of the feet. The paraneoplastic etiology of the eczema was suggested, and a left kidney tumor was diagnosed and operated. Rapid improvement of the keratoderma eczema was observed within a week of the tumor removal. The patient has no local and distant metastases.

Paraneoplastic skin manifestations as initial syndromes of malignant disease can help in the early diagnosis of cancer at a stage that allows complete cure.


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How to Cite

B. Georgieva, V. ., & V. Markova, T. . (2021). PARANEOPLASTIC ECZEMA AS AN INITIAL MANIFESTATION OF A RENAL CELL CARCINOMA. Proceedings of CBU in Medicine and Pharmacy, 2, 30-32.