CHANGES IN THE INTENSITY OF FREE RADICAL LIPID OXIDATION IN PATIENTS WITH BRONCHIAL ASTHMA WITH CONCOMITANT CHRONIC NON-CALCULOUS CHOLECYSTITIS
DOI:
https://doi.org/10.12955/pmp.v1.90Keywords:
Chronic non-calculous cholecystitis, bronchial asthma, free radical lipid oxidationAbstract
INTRODUCTION: The incidence rate of chronic non-calculous cholecystitis (CNCC) in the population is 35-38%, and in elderly patients it reaches to 65-72%. Free radical lipid oxidation (FRLO) plays a significant role in the development and progression of bronchial asthma (BA). The initiators of FRLO excessive activation can be the following: hypoxia, inflammation, immune damage to membranes and the imperfection of the antioxidant defense.
OBJECTIVE: To compare the intensity of FRLO processes in patients with BA and comorbid CNCC, and patients with BA and CNCC each without any comorbidities..
METHODS: The study was performed on 92 patients: 30 patients with BA (group 1), 30 patients with BA and comorbid CNCC (group 2), and 32 patients with CNCC (group 3). The control group consisted of 30 practically healthy persons (PHP). The number of compounds with isolated double bonds (IDB), diene conjugates (DC), ketodienes and conjugated trienes (K/CT), and malonic aldehyde (MA) in erythrocytes and blood plasma were determined.
RESULTS: In groups 1, 2, and 3, the content of IDB was higher in comparison with PHP by 1.4, 1.7, and 1.6 times respectively. In group 1, plasma K/CT was 12.0% higher, and DC was 1.5 times higher compared to the PHP group. In group 2, DC and K/CT were higher by 1.7 times and by 21.7% as compared with PHP. In group 1, plasma MA and red blood cell MA were higher by 18.0% and 29.8%. The highest content of plasma MA and red blood cell MA in group 2 of patients was 69.8% and 54.3% respectively. In group 3, plasma MA was 34.7% higher, and red blood cell MA was 44.4% higher compared to the normal values.
CONCLUSIONS: Intensification of FRLO processes leads to disruption of microcirculation and metabolic processes in the bronchial epithelium, supports local inflammatory process in the gallbladder and bronchi and promotes inhibition of tissue respiration with increased tissue hypoxia, which, in turn, leads to the progression of broncho-obstruction.
References
Cho Y.S., Moon H.B. (2010). The role of oxidative stress in the pathogenesis of asthma. Allergy Asthma Immunology Research 2(3), 183-187. https://doi.org/10.4168/aair.2010.2.3.183
Conte D., Fraquelli M., Giunta M., Conti C.B. (2011). Gallstones and liver disease: an overview. Journal of Gastrointestin and Liver Diseases, 20(1), 9-11. https://www.ncbi.nlm.nih.gov/pubmed/21451791
Dozor A.J. (2010). The role of oxidative stress in the pathogenesis and treatment of asthma. Annals of the New York Academy of Sciences, 1203(1), 133-137. https://doi.org/10.1111/j.1749-6632.2010.05562.x
Fabian, E., Pölöskey, P., Kósa, L., Elmadfa, I., Réthy, L. A. (2011). Activities of antioxidant enzymes in relation to oxidative and nitrosative challenges in childhood asthma. Journal of Asthma, 48(4), 351-357. https://doi.org/10.3109/02770903.2011.560319
Galimova E.S., Nurtdinova G.M., Kucher O.I. (2010). Digestive diseases in patients with bronchial asthma. Fundamental'nye issledovaniya [Fundamental Research]. 1. 36-40. (In Russian). http://www.fundamental-research.ru/ru/article/view?id=1605
International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) https://www.cdc.gov/nchs/icd/icd10cm.htm
Order of the Ministry of Health of Ukraine, about approval of Protocols for providing assistance to patients in pulmonary medicine https://zakononline.com.ua/documents/show/12588___540743
Gorbunov A.YU. (2011). Cholelithiasis: the role of motor and tonic disturbances and gallbladder inflammation in lithogenesis. Prakticheskaya medicina [Practical Medicine]. 1: 50-53. (In Russian).
Order of the Ministry of Health of Ukraine (June 13, 2005, № 271) «On Approval of Protocols on Provision of Medical Care in «Gastroenterology» Speciality» https://zakononline.com.ua/documents/show/72209___535629
Goriachkina N.M., Zhou S.D., Li C. (2010). Significance of oxidative stress parameters in bronchial asthma in patients with cold airway hyperresponsiveness. Byulleten' fiziologii i patologii dyhaniya [Bulletin Physiology and Pathology of Respiration]. 38. 12-15. (In Russian).
Lacy B.E., Patel N.K. (2017) Rome Criteria and a Diagnostic Approach to Irritable Bowel Syndrome. Journal of Clinical Medicine 6(11), 99. doi: 10.3390/jcm6110099
Iljukhina L.N., Krasavina N.P., Bashkatov V.A. (2010). Clinical and endoscopic features of lesion of gastrodyodenal zone in patients with bronchial asthma. Sibirskiy meditsinskiy zhurnal [Siberian Medical Journal]. 8. 72-74. (In Russian).
Downloads
Published
How to Cite
Issue
Section
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
The author is the copyright holder. Distribution license: CC Attribution 4.0.